ARV Facts

Facts about Antiretroviral Drugs

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Active substances: Lamivudine + Zidovudine
Manufacturer: GlaxoSmithKline (UK)

Extract from the prescribing information:

"COMBIVIR is not a cure for HIV infection and patients may continue to experience illnesses associated with HIV infection, including opportunistic infections. Patients should be advised that the use of COMBIVIR has not been shown to reduce the risk of transmission of HIV to others through sexual contact or blood contamination."

Known side effects: more immune deficiency

“Zidovudine, one of the two active ingredients in Combivir, has been associated with hematologic toxicity including neutropenia and severe anemia, particularly in patients with advanced human immunodeficiency virus (HIV) disease. Patients should be informed that the important toxicities associated with zidovudine are neutropenia and/or anemia.”

Neutropenia = Decrease of neutrophils, a subtype of white blood cells

The above has been extracted from the Combivir prescribing information on the GlaxoSmithKline webpages.