ARV Facts
Facts about Antiretroviral Drugs
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ARV damage to:
Protection against
ARV
organ damage
ARV damage to the heart
3'-Azido-3'-deoxythymidine (AZT) is a competitive inhibitor of thymidine phosphorylation in isolated rat heart and liver mitochondria.
Biochem Pharmacol. 2006 Jul 14;72(2):239-43. Epub 2006 Apr 25.
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Fetal mitochondrial heart and skeletal muscle damage in Erythrocebus patas monkeys exposed in utero to 3'-azido-3'-deoxythymidine.
AIDS Res Hum Retroviruses. 2000 May 1;16(7):635-44.
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AZT induces oxidative damage to cardiac mitochondria: protective effect of vitamins C and E.
Life Sci. 2004 Nov 19;76(1):47-56.
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AZT treatment induces molecular and ultrastructural oxidative damage to muscle mitochondria. Prevention by antioxidant vitamins.
J Clin Invest. 1998 July 1; 102(1): 4–9.
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